Ari Koskelainen
Department of Neuroscience and Biomedical Engineering

Ari Koskelainen

Professor

Contact information

Postal address
Otakaari 3
Mobile phone
+358503673768
Full researcher profile
https://research.aalto.fi/...

Description

My main research interests are the molecular mechanisms of photoreceptor cell signaling in the retina of the vertebrate eye, and increasingly, the mechanisms of neurodegeneration in certain retinal diseases. My research aims at developing novel therapies for age-related macular degeneration (AMD), and it involves the use of genetically modified mice and the use and development of state-of-the-art electrophysiological recording techniques and approaches, from single-cell recording to electroretinography (ERG) across the isolated retina and in vivo ERG.

Publications

Department of Neuroscience and Biomedical Engineering

In vivo monitoring of mouse retinal temperature by ERG photoresponses

Publishing year: 2019 EXPERIMENTAL EYE RESEARCH
Department of Neuroscience and Biomedical Engineering

Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp

Publishing year: 2019 Scientific Reports
Department of Neuroscience and Biomedical Engineering

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Publishing year: 2019 Redox Biology
Department of Neuroscience and Biomedical Engineering

Electrophysiological determination of phosphodiesterase-6 inhibitor inhibition constants in intact mouse retina

Publishing year: 2018 Toxicology and Applied Pharmacology
Department of Neuroscience and Biomedical Engineering

Transretinal ERG in studying mouse rod phototransduction

Publishing year: 2017 Investigative Ophthalmology and Visual Science
Department of Neuroscience and Biomedical Engineering, Department of Film, Television and Scenography

Spaces of the Abnormal, Poveglia II

Publishing year: 2017
Department of Neuroscience and Biomedical Engineering

A Novel Method for Mouse Retinal Temperature Determination Based on ERG Photoresponses

Publishing year: 2017 Annals of Biomedical Engineering
Department of Neuroscience and Biomedical Engineering

Lack of P4H-TM in mice results in age-related retinal and renal alterations

Publishing year: 2016 HUMAN MOLECULAR GENETICS
Department of Neuroscience and Biomedical Engineering

Retinal temperature determination ex vivo based on ERG photoresponses

Publishing year: 2015 Investigative Ophthalmology and Visual Science
Department of Neuroscience and Biomedical Engineering

Determination of basal PDE activity in WT, GCAPs(-/-) and GCAPs(-/-) rec(-/-) mice rods

Publishing year: 2015 Investigative Ophthalmology and Visual Science