Ari Koskelainen

Professori
Professori
T314 Dept. Neuroscience and Biomedical Engineering

My main research interests are the molecular mechanisms of photoreceptor cell signaling in the retina of the vertebrate eye, and increasingly, the mechanisms of neurodegeneration in certain retinal diseases. My research aims at developing novel therapies for age-related macular degeneration (AMD), and it involves the use of genetically modified mice and the use and development of state-of-the-art electrophysiological recording techniques and approaches, from single-cell recording to electroretinography (ERG) across the isolated retina and in vivo ERG.

Full researcher profile
https://research.aalto.fi/...

Contact information

Phone number
+358503673768

Publications

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder André, Ari Koskelainen 2022 Cells

ERG-based thermal dosimetry for subthreshold retinal laser therapy in anaesthetized pigs

Ossi Kaikkonen, Teemu Turunen, Mooud Amirkavei, Anna Meller, Johanna Ahlgren, Ari Koskelainen 2022 Investigative Ophthalmology & Visual Science

Retinal temperature determination based on photopic porcine electroretinogram

Ossi Kaikkonen, Teemu Tapio Turunen, Anna Meller, Johanna Ahlgren, Ari Koskelainen 2022 IEEE Transactions on Biomedical Engineering

A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6

Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D. Vargas, Virginia Kimonis, Krzysztof Palczewski 2021 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J. Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri, Juha M.T. Hyttinen, Ari Koskelainen, Kai Kaarniranta 2021 Oxidative Medicine and Cellular Longevity

Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors

Teemu Turunen, Ari Koskelainen 2021 Scientific Reports

Induction of heat shock protein 70 in mouse RPE as an in vivo model of transpupillary thermal stimulation

Mooud Amirkavei, Marja Pitkänen, Ossi Kaikkonen, Kai Kaarniranta, Helder André, Ari Koskelainen 2020 International Journal of Molecular Sciences

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta 2019 Redox Biology

Temporary Sanatorium

Ari Koskelainen 2019