Ari Koskelainen
Professori
Professori
T314 Dept. Neuroscience and Biomedical Engineering
My main research interests are the molecular mechanisms of photoreceptor cell signaling in the retina of the vertebrate eye, and increasingly, the mechanisms of neurodegeneration in certain retinal diseases. My research aims at developing novel therapies for age-related macular degeneration (AMD), and it involves the use of genetically modified mice and the use and development of state-of-the-art electrophysiological recording techniques and approaches, from single-cell recording to electroretinography (ERG) across the isolated retina and in vivo ERG.
Full researcher profile
https://research.aalto.fi/...
E-post
ari.koskelainen@aalto.fi
Telefonnummer
+358503673768
Publikationer
Non-damaging laser treatment with electroretinography-based thermal dosimetry activates hormetic heat response in pig retinal pigment epithelium
Mooud Amirkavei, Ossi Kaikkonen, Teemu Turunen, Anna Meller, Johanna Åhlgren, Anders Kvanta, Helder André, Ari Koskelainen
2025
Nature Communications
Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function : Studies From Ex Vivo ERG
Sama Saeid, Frans Vinberg, Ari Koskelainen
2025
Investigative Ophthalmology and Visual Science
Closed-perfusion transretinal ERG setup for preclinical drug and nanostructure testing
Sama Saeid, Marja Pitkänen, Emma Ilonen, Jukka Niskanen, Heikki Tenhu, Frans Vinberg, Ari Koskelainen
2024
IEEE Transactions on Biomedical Engineering
Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder André, Ari Koskelainen
2022
Cells
ERG-based thermal dosimetry for subthreshold retinal laser therapy in anaesthetized pigs
Ossi Kaikkonen, Teemu Turunen, Mooud Amirkavei, Anna Meller, Johanna Ahlgren, Ari Koskelainen
2022
Investigative Ophthalmology and Visual Science
Retinal temperature determination based on photopic porcine electroretinogram
Ossi Kaikkonen, Teemu Tapio Turunen, Anna Meller, Johanna Ahlgren, Ari Koskelainen
2022
IEEE Transactions on Biomedical Engineering
A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6
Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D. Vargas, Virginia Kimonis, Krzysztof Palczewski
2021
Journal of Pharmacology and Experimental Therapeutics
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice
Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J. Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri, Juha M.T. Hyttinen, Ari Koskelainen, Kai Kaarniranta
2021
Oxidative Medicine and Cellular Longevity
Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors
Teemu Turunen, Ari Koskelainen
2021
Scientific Reports
Induction of heat shock protein 70 in mouse RPE as an in vivo model of transpupillary thermal stimulation
Mooud Amirkavei, Marja Pitkänen, Ossi Kaikkonen, Kai Kaarniranta, Helder André, Ari Koskelainen
2020
International Journal of Molecular Sciences