Department of Neuroscience and Biomedical Engineering

Molecular Nanoengineering

The Molecular Nanoengineering group operates at the interface between nanoscience, molecular self-assembly, DNA nanotechnology and nanoplasmonics with particular focus on DNA-based artificial molecular systems with functionalities tailored for biosensing, nanophotonics and biomimetics.

Members

Dr. Svitlana Filonenko, postdoc (now: group manager at MPI of Colloids and Interfaces)
Susanna Hällsten, MSc
Arttu Lehtonen, MSc (now: doctoral candidate in Juho Pokki lab)
Ilona Leppänen, MSc (now: research scientist at VTT)
Nguyen Hoang Vu, MSc

J. Ryssy, A. K. Natarajan, J. Wang, A. J. Lehtonen, M.‐K. Nguyen, R. Klajn, A. Kuzyk (2021): Light‐Responsive Dynamic DNA‐Origami‐Based Plasmonic Assemblies. Angewandte Chemie International Edition 60: 5859.
M.-K. Nguyen, V. H. Nguyen, A. K. Natarajan, Y. Huang, J. Ryssy, B. Shen, A. Kuzyk (2020): Ultrathin Silica Coating of DNA Origami Nanostructures. Chemistry of Materials 32: 6657.
P. Zhan, M. J. Urban, S. Both, X. Duan, A. Kuzyk, T. Weiss, N. Liu (2019): DNA-assembled Nanoarchitectures with Multiple Components in Regulated and Coordinated Motion. Science Advances 5: eaax6023.
M-K Nguyen, A. Kuzyk (2019): Reconfigurable Chiral Plasmonics beyond Single Chiral Centers. ACS Nano 13:13615.
Q. Liu, A. Kuzyk, M. Endo, I. Smalyukh (2019): Plasmonic DNA-Origami with Photo-Switchable Chirality in Liquid Crystals. Optics Letters 44:2831.
T. Funck, F. Nicoli, A. Kuzyk, T. Liedl (2018): Sensing Picomolar Concentrations of RNA using Switchable Plasmonic Chirality. Angewandte Chemie International Edition 57:13495.
Y. Huang, M-K Nguyen, A. K. Natarajan, V. H. Nguyen, A. Kuzyk (2018): DNA Origami-Based Chiral Plasmonic Sensing Device. ACS Applied Materials & Interfaces 10:44221.
A. Kuzyk, R. Jungmann, G. P. Acuna, N. Liu (2018): DNA Origami Route for Nanophotonics. ACS Photonics 5:1151–1163.
M. J. Urban, S. Both, C. Zhou, A. Kuzyk, K. Lindfors, T. Weiss, N. Liu (2018). Gold Nanocrystal-Mediated Sliding of Doublet DNA Origami Filaments. Nature Communications 9: 1454.
A. Kuzyk, M. J. Urban, A. Idili, F. Ricci, N. Liu (2017): Selective Control Of Reconfigurable Chiral Plasmonic Metamolecules. Science Advances 3:e1602803.
A. Kuzyk, Y. Yang, X. Duan, S. Stoll, A. O. Govorov, H. Sugiyama, M. Endo, N. Liu (2016): A Light-Driven Three-Dimensional Plasmonic Nanosystem that Translates Molecular Motion into Reversible Chiroptical Function. Nature Communications 7:10591.
A. Kuzyk, R. Schreiber, H. Zhang, A.O. Govorov, T. Liedl, N. Liu (2014): Reconfigurable 3D Plasmonic Metamolecules in the Visible Wavelength Range. Nature Materials 13:862.
M.B. Scheible, G. Pardatscher, A. Kuzyk, F.C. Simmel (2014): Single Molecule Characterization of DNA Binding and Strand Displacement Reactions on Lithographic DNA Origami Microarrays. Nano Letters 14:1627.
R. Schreiber, N. Luong, Z. Fan, A. Kuzyk, P.C. Nickels, T. Zhang, D.M. Smith, B. Yurke, W. Kuang, A. O. Govorov, T. Liedl (2013): Chiral Plasmonic DNA Nanostructures with Switchable Circular Dichroism. Nature Communications 4:2948.
A. Kuzyk, R. Schreiber, Z. Fan, G. Pardatscher, E.-M. Roller, A. Högele, F. C. Simmel, A. O. Govorov, T. Liedl (2012): DNA-based Self-Assembly of Chiral Plasmonic Nanostructures with Tailored Optical Response. Nature 483:311.

Collaborations

Prof. Laura Na Liu, University of Heidelberg

Prof. Rafal Klajn, Weizmann Institute of Science

Prof. Guillermo P. Acuna, University of Fribourg

Electronically controlled molecular machines would be faster as well as easier to manufacture, as they would not need to rely on sophisticated chemical synthesis.