Chemical Engineering in Aqueous Systems
The group, led by Prof. Marjatta Louhi-Kultanen, is studying the unit operations of aqueous systems and the solid-liquid phases equilibria.
Water has an important role in many unit operations in applications of the chemical industry, hydrometallurgy, wood processing, food production, the metal industry and biorefining. For instance, different types of unit operations of water systems include precipitation, crystallization, freezing, eutectic freeze crystallization, drying, evaporation, absorption and adsorption, dissolution, heat transfer and post-processing of liquids and solids.
For a deeper understanding and modelling of production processes, it is also important to know the states of equilibrium between multiphase systems. The gas-liquid, liquid-liquid, and solid-liquid states of equilibrium in water systems need to be known with a sufficient degree of precision.
Water has an important role in many unit operations in applications of the chemical industry, hydrometallurgy, wood processing, food production, the metal industry and biorefining. For instance, different types of unit operations of water systems include precipitation, crystallization, freezing, eutectic freeze crystallization, drying, evaporation, absorption and adsorption, dissolution, heat transfer and post-processing of liquids and solids.
For a deeper understanding and modelling of production processes, it is also important to know the states of equilibrium between multiphase systems. The gas-liquid, liquid-liquid, and solid-liquid states of equilibrium in water systems need to be known with a sufficient degree of precision.

Recent research activities:
- Separation and purification of valued compounds from biorefineries, metals from waste and side streams, nutrients and other recyclable materials by crystallization and precipitation.
- Identification of critical impurities and their separation from solutions.
- Crystallization of mesocrystals for pharmaceutical applications.
- Regeneration of chemicals: concentration of aqueous solutions containing green solvents by freezing.
- Pre-treatment of aqueous electrolyte solutions to remove fine particles by microfiltration and organic compounds by adsorption containing.
- Real-time monitoring of crystal growth and nucleation kinetics and separation efficiency of microfiltration.

Our lab and facilities:
- We have good facilities consisting of a laboratory scale stirred tank station which allows studies on continuous, semi-batch and batch process mode at ambient or lower pressures. The station is equipped with a calorimeter and accurate temperature control system. Various crystallization methods, such as cooling crystallization, evaporative crystallization, reactive crystallization and anti-solvent crystallization, can be investigated.
- Melt crystallization devices for layer and suspension crystallization studies.
- Solid-liquid equilibria research based on thermal analysis methods, solubility measurements and optical detection of saturation point of solutions.
- Realtime monitoring of chord lengths of particulates in fluids.
- Thermodynamic modeling of electrolyte and non-electrolyte solutions.
- Vacuum and pressure test filters for filterability studies to determine principle filtration parameters.
Research group members:
Mitra Ila
Doctoral candidate

Related content:
Could mesocrystals make medication more effective? - Marie Skłodowska-Curie Fellowship was awarded to Dr. Rajaboopathi Mani
More water soluble the drug is the faster and more effective it works. Many new drug molecules have low solubility and that could limit their effectiveness when taken by mouth.

New natural freezing method offers energy savings in water purification
Freezing winter temperatures can be put to good use in improving the cost and energy efficiency of wastewater purification.
Latest publications:
Experimental and CFD study on influence of viscosity on layer melt crystallization
Nahla Osmanbegovic, Ville Alopaeus, Bing Han, Ville Vuorinen, Marjatta Louhi-Kultanen
2022
Separation and Purification Technology
Recovery of Lanthanum from Aqueous Solutions by Crystallization as Lanthanum Sodium Sulfate Double Salt
Arshe Said, Mari Lundström, Marjatta Louhi-Kultanen
2022
JOM
Semi-batch evaporative crystallization and drying of cobalt sulphate hydrates
Jianxin Zhang, Arshe Said, Bing Han, Marjatta Louhi-Kultanen
2022
Hydrometallurgy
Synthesis, structural, vibrational, molecular docking and nonlinear optical studies of (E)-N′-(2,3-dimethoxybenzylidene)-4-fluorobenzohydrazide
Jeeva P, Barathi D, Rajaboopathi Mani, David Stephen A, Marjatta Louhi-Kultanen, Vinitha G, Abdullah G. Al-Sehemi
2022
Journal of Molecular Structure
CFD Study on Heat Transfer in a Layer Melt Crystallizer
Nahla Osmanbegovic, Ville Alopaeus, Ville Vuorinen, Marjatta Louhi-Kultanen
2021
Semi-Batch Evaporation Crystallization for Cobalt Sulfate Recovery
Jianxin Zhang, Arshe Said, Bing Han, Marjatta Louhi-Kultanen
2021
Batch crystallization of xylitol by cooling, evaporation and anti-solvent addition
Anna Zaykovskaya, Marjatta Louhi-Kultanen, Erik Temmel, Manfred Stepanski, Baudine Gevers Deynoot, Ed de Jong
2021
Organic Mesocrystals: A new strategy to enhance the drug dissolution
Rajaboopathi Mani, Marjatta Louhi-Kultanen
2021
Structural, theoretical and third order nonlinear optical properties of (E)-N’-(4-chlorobenzylidene)-4-fluorobenzohydrazide monohydrate
N. Latha, D. Barathi, M. Uthaya Kumar, K. N. Vennila, G. Vinitha, Rajaboopathi Mani, Marjatta Louhi-Kultanen, Fehmi Bardak, Ahmet Atac, Etem Kose
2021
Molecular Crystals and Liquid Crystals
Structural, spectral, experimental, and theoretical investigations of (E)-4-fluoro-N′-(pyridin-2-ylmethylene)benzohydrazide monohydrate
N. Latha, D. Barathi, M. Uthaya Kumar, G. Vinitha, Rajaboopathi Mani, Ahmet Atac, Etem Kose
2021
RESEARCH ON CHEMICAL INTERMEDIATES