News

Nanofiber scaffolds demonstrate new features in the behaviour of stem and cancer cells

A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development.
Biomedical scaffold

Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.

“This unique hybrid nano-network allows for an exceptional combination of selective guidance stimuli for stem cell development, variations in immune reactions, and behavior of cancer cells”, says Professor Michael Gasik from Aalto University.

These scaffolds, for example, were shown to be able to direct the preferential orientation of human mesenchymal stem cells, similarly to neurogenic lineage, to suppress of major inflammatory factors expression and to immobilize cancer cells.

The selective downregulation of specific inflammatory cytokines may be anticipated as a new tool for understanding the human immune system and ways of treating associated diseases. The effects observed are self-regulated by cells only, without the side effects usually arising from the use of external factors.

New scaffolds may help to control the fate of stem cells, such as development towards axons and neurites formation. This is important, for instance, in the development of Alzheimer’s disease therapy. The discovery may also be very useful in developing new cancer tumour models, understanding how cancer develops, and developing new cancer therapies.

Fluorescent images of breast carcinoma cell line showing the morphological changes of cells grown on vertical GAIN scaffolds.

The results of the study were published in Nature Scientific Reports. Aalto University made the study in collaboration with Protobios, CellIn Technologies, and Tallinn University of Technology.

 

For more information:

Professor Michael Gasik
Aalto University
[email protected]
Tel. +358 50 5609511 

 

Kazantseva, J. et al. Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour. Sci. Rep. 6, 30150; doi: 10.1038/srep30150 (2016).

  • Published:
  • Updated:
Share
URL copied!

Read more news

Sustainability day
Research & Art, University Published:

Sustainability Science Days 2022: Call for Abstracts

Sustainability Science Days 2022:Call for Abstracts
Device
Research & Art Published:

Experiment with turnstiles of single electrons shows way towards new power standard

Researchers at Aalto University propose method of transducing frequency to power
Päivi Törmä ja Sebastiaan van Dijken
Press releases, Research & Art Published:

Guiding spin waves with light could lead to faster and much more energy efficient computing

Major new research project at Aalto University aims to develop new type of computing device that eliminates massive amounts of waste heat produced by current devices
The picture shows the School of Business in winter time and during sunset. The photo was taken by Mikko Raskinen from Aalto University.
Research & Art Published:

Climate change is serious business

According to Senior University Lecturer Leena Lankoski, there are both compelling sustainability reasons and compelling business reasons for companies to urgently address their environmental impact.