News

Cells migrate collectively by intermittent bursts of activity

Increased understanding of the cell migration may lead to the development of new therapies for controlling invasive tumour cells.

When you have got a wound and it starts healing, cells start to migrate in your body to the wound. They are driven by active internal forces to invade the available space. Cell migration doesn't only take place when you are getting better. In cancer invasion cells also migrate collectively. Tissue formation during embryonic development requires the orchestrated movement of cells to specific locations. In general, cell migration is a central process in the development and maintenance of multicellular organisms.

Researchers of Aalto University, University of Milan and their research partners have now discovered that this motion occurs by intermittent bursts of activity. It can be described by universal scaling laws similar to the ones observed in other driven systems outside of biology.

- Our results demonstrate that living systems display universal non-equilibrium critical fluctuations, induced by cell mutual interactions, that are usually associated to externally driven inanimate media, says Oleksandr Chepizhko, Postdoctoral Researcher at Aalto University.

 

Researchers substantiated the analogy between collective cell migration and depinning by revealing and characterizing widely distributed bursts of activity in the collective migration of different types cells over different substrates and experimental conditions. After  that, they compared the experiments with simulations of a computational model of active particles. They found that in all these cases the statistical properties of the bursts follow universal scaling laws that are quantitatively similar to those observed in driven disordered systems.

Errors during cell migration may have serious consequences. For instance, errors may cause vascular disease, intellectual disability, metastasis or tumour formation. Increased understanding of the mechanism by which cells migrate may lead to the development of new therapeutic strategies for controlling, for example, invasive tumour cells.

Photo (above): This is how cells are migrating. He-La cells - the oldest and most commonly used human cell line - on collagen substrate: time evolution of the front superimposed on the first frame of experiment. Image: Oleksandr Chepizhko, Aalto University

 

Research article: Oleksandr Chepizhko et al.: Bursts of activity in collective cell migration. PNAS 2016. DOI 10.1073/pnas.0709640104

  • Published:
  • Updated:
Share
URL copied!

Related news

ARTS open science roadshow, pic of the session
Research & Art Published:

European Open Science Cloud (EOSC) Finnish Forum webinar on 25th January

One of the speakers is Karel Luyben, the first president of the EOSC Association and a member of board at Aalto University.
Installation Talk 2020, Jarkko Niiranen
Research & Art Published:

Professor Jarkko Niiranen on the computational mechanics of microarchitectural solids and structures

'When developing models, we spend a lot of time on mathematical physics, numerical mathematics and computer programming, but the fundamental concepts of mechanics remain the same' says Niiranen in his installation talk.
A photo showing Dr. Dorothea Golze
Research & Art Published:

Computational physicist Dorothea Golze receives prestigious Emmy Noether Award

Dorothea Golze received funding from the German Research Foundation within the Emmy Noether Programme to establish her own junior research group at the Technical University of Dresden.
Dronen ottama kuva Otakaari 1:sestä, kuva: Mikko Raskinen
Research & Art Published:

How do you know where a drone is flying without a GPS signal?

In Jouko Kinnari's doctoral dissertation, the location of a drone can be determined using map data and sensors.