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Ultrasound-enhanced fine-needle aspiration biopsy — from the unmet need to the first clinical experience

Prof. Heikki Nieminen will give a seminar presentation to celebrate the recent advances of ultrasound-enhanced fine-needle aspiration biopsy (USeFNAB) research and the first clinical experiences. Refreshments will be served afterwards.

Title: Ultrasound-enhanced fine-needle aspiration biopsy — from the unmet need to the first clinical experience

Presenter: Heikki Nieminen

Place: F336, Otakaari 3, pulla served in the coffee room afterwards.

Time: 19.12.2023, seminar at 13:00, pulla starting around 13:30–13:45

Abstract: The lifetime risk for getting cancer is nearly 40%. While imaging methods such as magnetic resonance or ultrasound imaging can enable locating a tumor within the body, almost all solid tumors require a tissue sample for a diagnosis and defining the right treatment. Fine-needle aspiration biopsy (FNAB) is one of the most common methods to obtain tissue samples from soft tumors. Unfortunately, 10-30% of FNABs fail to provide a diagnostically adequate sample, leading to a delayed treatment and poorly informed treatment decisions, both increasing the likelihood to compromise treatment outcomes. Ultrasound-enhanced fine-needle aspiration biopsy (USeFNAB) is a novel biopsy method developed by Medical Ultrasonics Laboratory (Aalto University) to address the clinical unmet need arising from the shortcomings of FNAB. USeFNAB provides ultrasonic flexural oscillations at the tip of a conventional FNAB needle increasing the tissue yield by 2.5-3x compared to the same needle without ultrasound. The increased tissue yield improves the likelihood to collect pathological cells, potentially enhancing diagnostic precision and treatment outcomes. This presentation provides an overview to the journey of USeFNAB starting from the identification of the unmet clinical need all the way to the study of physical needle-tissue -interactions, clinical device development and results from the first-in-human tumor biopsies.

HUS performs the first biopsy in human with an ultrasonic medical needle developed at Aalto

The Aalto researchers developed a novel needle instrument that concentrates ultrasound energy at the needle tip to improve sample collection.

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From left: Mira Naukkarinen, Yohann Le Bourlout, Katri Aro, Kristofer Nyman, Minna Rehell and Sanjeev Ranjan. Photo byt Kalle Kataila.
Department of Neuroscience and Biomedical Engineering
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