Markus Linder

T107 Bioproducts and Biosystems


I work on making different microbes do useful things. Microbes are incredibly versatile systems for producing different types of materials and chemicals. The microbes can produce proteins that we build materials from. These materials can be something like silk, or cellulose. The special thing is that we can use genetic engineering to program so that the microbes make the materials or chemicals that we want. We also study how microbes communicate with each other in order to get them working better together to make the things we want them to do. When the microbes have made components or chemicals to make materials form our real challenge is to actually construct the materials. This involves using different assembly techniques and characterization. In the future I think that this way of using engineered microbes to produce materials and chemical will allow a sustainable green technology.

Also look at: The HYBER Centre.

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Honors and awards

Leading edge-lecturer

Award or honor granted for academic or artistic career Department of Bioproducts and Biosystems Jan 2015

VTT Prize for Scientific Excellence

Award or honor granted for a specific work Department of Bioproducts and Biosystems Jan 1998

Research groups

  • Biomolecular Materials, Professor


Biomolecular Click Reactions Using a Minimal pH-Activated Catcher/Tag Pair for Producing Native-Sized Spider-Silk Proteins

Ruxia Fan, Johanna Hakanpää, Karoliina Elfving, Helena Taberman, Markus B. Linder, A. Sesilja Aranko 2023 Angewandte Chemie - International Edition

Shaping Liquid Droplets on an Active Air–Ferrofluid Interface

P. A. Diluka Harischandra, Teemu Välisalmi, Zoran Cenev, Markus Linder, Quan Zhou 2023 Langmuir

Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant Pseudomonas aeruginosa and Acinetobacter baumannii

Christopher Jonkergouw, Ngong Kodiah Beyeh, Ekaterina Osmekhina, Katarzyna Leskinen, S. Maryamdokht Taimoory, Dmitrii Fedorov, Eduardo Anaya-Plaza, Mauri A. Kostiainen, John F. Trant, Robin H.A. Ras, Päivi Saavalainen, Markus B. Linder 2023 Nature Communications

pH dependence of the assembly mechanism and properties of poly(l-lysine) and poly(l-glutamic acid) complexes

Tuuva Kastinen, Dawid Lupa, Piotr Bonarek, Dmitrii Fedorov, Maria Morga, Markus B. Linder, Jodie L. Lutkenhaus, Piotr Batys, Maria Sammalkorpi 2023 Physical Chemistry Chemical Physics

Highly Hydrophobic Films of Engineered Silk Proteins by a Simple Deposition Method

Teemu Välisalmi, Nelmary Roas-Escalona, Kristoffer Meinander, Pezhman Mohammadi, Markus B. Linder 2023 Langmuir

Pulling and analyzing silk fibers from aqueous solution using a robotic device

Teemu Välisalmi, Houari Bettahar, Quan Zhou, Markus B. Linder 2023 International Journal of Biological Macromolecules

On the mechanism for the highly sensitive response of cellulose nanofiber hydrogels to the presence of ionic solutes

Suvi Arola, Zhennan Kou, Bart J.M. Rooijakkers, Rama Velagapudi, Maria Sammalkorpi, Markus B. Linder 2022 Cellulose

Robotic Fiber Fabrication based on Solidification Force Control

Houari Bettahar, Teemu Valisalmi, Markus Linder, Quan Zhou 2022 Proceedings of MARSS 2022 - 5th International Conference on Manipulation, Automation, and Robotics at Small Scales

In vivo liquid–liquid phase separation protects amyloidogenic and aggregation-prone peptides during overexpression in Escherichia coli

Bartosz Gabryelczyk, Reema Alag, Margaret Philips, Kimberly Low, Anandalakshmi Venkatraman, Bhuvaneswari Kannaian, Xiangyan Shi, Markus Linder, Konstantin Pervushin, Ali Miserez 2022 Protein Science

Recombinant protein condensation inside E. coli enables the development of building blocks for bioinspired materials engineering – Biomimetic spider silk protein as a case study

Bartosz Gabryelczyk, Fred-Eric Sammalisto, Julie-Anne Gandier, Jianhui Feng, Grégory Beaune, Jaakko V.I. Timonen, Markus B. Linder 2022 Materials Today Bio