Plasmonic biosensors enable development of new easy-to-use health tests

A biosensor developed at Aalto University enables creating a range of new health tests similar to home pregnancy tests.
Visualizing the specular reflection color by a blackbody substrate. The carriers containing Ag nanoparticles are covered with various dielectrics of AlN, SiO2 and the composites thereof that are placed on a black background to enhance the reflectivity contrast of various colours at a normal angle of incidence. (Photo: Aalto University)

The plasmonic biosensor can detect diseased exosomes even by the naked eye. Exosomes, important indicators of health conditions, are cell-derived vesicles that are present in blood and urine.

A rapid analysis by biosensors helps recognize inflammatory bowel diseases, cancer and other diseases rapidly and start relevant treatments in time. In addition to using discovery in biomedicine, industry may use advanced applications in energy.

Researchers created a new biosensor by depositing plasmonic metaparticles on a black, physical body that absorbs all incident electromagnetic radiation. A plasmon is a quantum of plasma oscillation. Plasmonic materials have been used for making objects invisible in scientific tests. They efficiently reflect and absorb light. Plasmonic materials are based on the effective polarizabilities of metallic nanostructures.

“It is extraordinary that we can detect diseased exosomes by the naked eye. The conventional plasmonic biosensors are able to detect analytes solely at a molecular level. So far, the naked-eye detection of biosamples has been either rarely considered or unsuccessful”, says Professor Mady Elbahri from Aalto University.

Plasmonic dipoles are famous for their strong scattering and absorption. Dr. Shahin Homaeigohar and Moheb Abdealziz from Aalto University explain that the research group has succeeded in demonstrating the as-yet unknown specular reflection and the Brewster effect of ultrafine plasmonic dipoles on a black body host.

“We exploited it as the basis of new design rules to differentiate diseased human serum exosomes from healthy ones in a simple manner with no need to any specialized equipment”, says Dr. Abdou Elsharawy from the University of Kiel.

The novel approach enables a simple and cost-effective design of a perfect colored absorber and creation of vivid interference plasmonic colors.

According to Elbahri, there is no need to use of sophisticated fabrication and patterning methods. It enables naked-eye environmental and bulk biodetection of samples with a very minor change of molecular polarizability of even 0.001%.

The study was published today in Advanced Materials.

For more information:
Professor Mady Elbahri, Aalto University
[email protected]
Tel. +358 50 464 8990

Article: Mady Elbahri, Moheb Abdelaziz, Shahin Homaeigohar, Abdou ElSharawy, Mehdi Keshavarz Hedayati, Christian Röder, Mamdouh El Haj Assad, and Ramzy Abdelaziz: Plasmonic Metaparticles on a Blackbody Create Vivid Reflective Colors for Naked-eye Environmental- and Clinical Bio-detection. Advanced Materials 2017. DOI: 10.1002/adma.201704442

Related news

Research & Art Published:

Applying for the Academy of Finland September call? Get help with your Data Management Plan (DMP)!

Data Management Specialists will help you to prepare a competitive Data Management Plan!
Syväoppimismenetelmä auttaa tunnistamaan diabeteksen aiheuttamia silmäsairauksia.
Research & Art Published:

Deep learning model developed by Finnish AI researchers detects diabetic eye diseases accurately

Finnish AI researchers have developed a deep learning system that shows great potential in detecting diabetic eye diseases
Mika Juuti studied the use of machine learning in information security for his dissertation.
Research & Art Published:

Information security researchers need to anticipate the next step of an attacker

In his doctoral studies, Mika Juuti focused on machine learning methods in information security
Photoactive rod-like virus bundle schematic
Press releases, Research & Art, University Published:

Dyes and viruses create new composite material for photooxidation reactions

A recent study shows that native viruses can be employed as a scaffold to immobilise photoactive molecules to potentially oxidise organic pollutants present in wastewater, under visible light irradiation
  • Published:
  • Updated:
Share
URL copied!