Department of Neuroscience and Biomedical Engineering

Medical Ultrasonics Laboratory (MEDUSA)

The main research goal of MEDUSA is to create novel technologies exploiting non-linear ultrasonics for therapeutic or diagnostic purposes.

Ultrasound provides unconventional approaches to manipulate material from micro-scale, e.g. drug carriers or cells, to macro-scale, e.g. tissue or organs. Ultrasound can be used create force fields through the skin, in a non-destructive manner, to influence targets inside the body from a distance. This allows one to develop non-invasive applications and technologies for advanced medical diagnostics and interventions. Ultrasound can also add value to small minimally invasive medical instruments by activating them based on non-linear ultrasound approaches. Our research has recently contributed to establishing several medical technology companies.

Our current interests include e.g. ultrasound-enhanced fine-needle biopsy (USeFNB), ultrasound-enhanced medical needles, ultrasonic scalpels, ultrasonic drug delivery, and ultrasonic gene transfection. We also conduct basic research on acoustic phenomena that have the potential to be translated to medical applications in the future.
MEDUSA

We have multi-national multi-disciplinary team with expertise in physics, biomedical engineering, electrical engineering, acoustics, medicine and business. 

The laboratory is headed by Prof. Heikki Nieminen.

Recent news

  • 01.07.2024: We are happy to announced that the study by Drago-González et al. entitled "Ultrasonic Healing of Plastrons" has been published today in Advanced Science. Please, find the article here: https://doi.org/10.1002/advs.202403028
  • 04.06.2024: The study by Le Bourlout et al. entitled "Ultrasound-Enhanced Fine-Needle Biopsy Improves Yield in Human Epithelial and Lymphoid Tissue" has been published today in Ultrasound in Medicine and Biology. Please, find the article here: https://doi.org/10.1016/j.ultrasmedbio.2024.04.015
  • 20.05.2024: We are pleased to welcome our new Post-Doctoral Researcher Daniel Veira-Canle to join MEDUSA.
  • 15.03.2024: We would like to welcome our new Post-Doctoral Researcher, William Cailly to join MEDUSA.
  • 14.12.2023: We are happy to announce that the ultrasound-enhanced fine-needle biopsy (USeFNB)received the Aalto School of Science Innovation of the Year award. Read more here: https://www.aalto.fi/en/news/sci-awards-2023-celebrate-the-people-of-our-school
  • 22.11.2023: Our paper by Le Bourlout et al. entitled "Multi-modal transducer-waveguide construct coupled to a medical needle" has been published today in The Journal of the Acoustical Society of America. Please, find the article here: https://doi.org/10.1121/10.0022326
  • 6.10.2023: We successfully conducted the first human experiment sampling a tumor using ultrasound-enhanced fine-needle biopsy developed at our laboratory. The new method is expected to improve cancer management in the future. For more information, read the team interview here: https://www.aalto.fi/en/news/hus-performs-the-first-biopsy-in-human-with-an-ultrasonic-medical-needle-developed-at-aalto
  • 14.9.2023: We would like to welcome our new Doctoral Researcher Nele van Giel to join MEDUSA.
  • 12.10.2022: Our paper by Bunni et al. entitled "Needle bevel geometry influences the flexural deflection magnitude in ultrasound-enhanced fine-needle biopsy" has been published today in Scientific Reports. Please, find the article here: https://doi.org/10.1038/s41598-022-20161-3
  • 07.10.2022: Congratulation to D.Sc Emanuele Perra for completing his doctoral study.
  • 1.9.2022: We would like to welcome Dr. Thomas Andreae, Post-doctoral Researcher Sanjeev Ranjan and Doctoral Researcher Ona Westerlund to join MEDUSA.
  • 6.6.2022: We would like to welcome our new Doctoral Researcher Alex Drago-Gonzalez to join MEDUSA.
  • 30.5.2022: Jane and Aatos Erkko foundation has provided us a major grant to work for development of a novel gene delivery method.
  • 13.6.2022: Our paper by Perra et al. entitled "An Ultrasonically Actuated Needle Promotes the Transport of Nanoparticles and Fluids" has been published today in The Journal of Acoustical Society of America. Please, find the article here: https://doi.org/10.1121/10.0012190
  • 02.6.2022: We are happy to announce that our paper by Perra et al. entitled "An ultrasonically actuated fine-needle creates cavitation in bovine liver" has been published today in The Journal of Acoustical Society of America. Please, find the article here: https://asa.scitation.org/doi/full/10.1121/10.0010534

Recent research

Ultrasound-enhanced fine-needle aspiration biopsy (USeFNAB)

Fine-needle biopsy is a common medical procedure for obtaining a tissue sample for diagnostic purpose. This procedure, broadly used in cancer detection, suffers from obtaining and inadequate sample up to 30% of cases.

We are developing a new method, USeFNB, in which ultrasound is used to actuate the very tip of the needle (Perra et al. Scientific Reports. 2021;11:8234; Le Bourlout et al. IEEE IUS 2020). The non-linear interactions of the needle tip and tissue lead to increase in the amount of tissue by 3-5x compared to fine-needle aspiration biopsy (FNAB) using the same needle. The improvement in tissue quantity is demonstrated in the Figure 1. Importantly, the obtained tissue mass increases, while no major effect on sample quality, as demonstrated by histological assessment. The feasibility of the USeFNAB method has been demonstrated recently (Perra et al. 2021) as summarized in the following:

USeFNAB

The comparison of the FNAB and USeFNAB procedures with typical tissue mass obtained are exemplified in the following video:

We have further developed the power efficiency of USeFNAB concept to potentially allow batterization of USeFNAB in the future (Le Bourlout et al. 2020). Following optimization, we have reached an electrical-to-acoustic power -efficiency of up to 69%. This result suggests that the developed waveguide structure allows to drive the system with low power electronics permitting miniaturization and portability of the USeFNAB device.

USeFNAB

Ultrasound-enhanced medical needle (USeMN)

USeMN could have several potential applications in the future, beyond USeFNAB. Inside liquid, an ultrasonically actuated medical needle can be made to vibrate rapidly producing cavitation bubbles. These bubbles grow and can collapse rapidly. We have recorded accelerations of bubble-water boundary of up to 20 000 G (Perra et al. 2021). With further advancements of the cavitation events localized near the tip of the medical needle could be used for fractionate tissue (histotripsy) such as tumors or even enhance drug delivery by improving tissue permeability. Importantly, the cavitation can be made to exhibit only at the tip of the needle providing predictability to the spatial location of cavitation and, therefore, allows the control safety aspects associated with cavitation. The following high-speed video exemplifies cavitation events at 33 kHz observed near the tip of a USeMN:

While the USeMD is embedded in air, liquid delivered to a tip of a USeMN can be atomized to small droplets using capillary waves delivered to the needle tip (Perra et al. 2021). This approach could be used to deliver and disperse drugs on tissue surfaces within gas-filled bodily cavities, e.g. in the respiratory system. Importantly, we demonstrated that the droplet size can be controlled by the selection of the ultrasound frequency (Perra et al. 2021). Atomization of water at 33 kHz is exemplified in the following high-speed video:

We have also demonstrated that the USeMN is capable of transporting microparticles (Perra et al. 2021). This could be advantageous in various drug and gene delivery applications, since the approach could contribute to the delivery beyond the reach of a traditional needle. The transport of microparticles by 33 kHz ultrasound inside water is demonstrated in the following:

Ultrasonically actuated scalpels


Ultrasonic scalpels are known for their capability of cutting tissue. Usually such technologies employ actuation along the longitudinal axis of the blade. However, transversely oscillating motion has received less attention. In this study, our objective is to broaden understanding of the behaviour of different wave modes emitted from a transversely oscillating scalpel blade, modelled as a wedge embedded in viscoelastic material representing soft tissue. Our simulations demonstrate the different wave modes emitted from the needle. The following 2D velocity surface map shows the vibrating wedge oscillating at 30 kHz on the surface of viscoelastic medium representing soft tissue, captured at a time step 0.66 ms. The x and y components of velocity (m/s) are shown respectively on the left and right:

Wave propagation in a media due to ultrasound

Ultrasonic levitation of particles

Ultrasound can be used to levitate and trap small particles. This approach allows one to manipulate and sort small objects, such as micro-spheres and cells, without touching them. The following example demonstrates how micro-spheres are trapped inside liquid along the axis of the ultrasound propagation as well as along the axis perpendicular to the ultrasound propagation:

Ultrasonic levitation of particles

Publications

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