Alexander Frey

Visiting Professor
Visiting Professor
T107 Bioproducts and Biosystems

I received my D.Sc. from the Swiss Federal Institute of Technology (ETH Zürich) in the field of Biotechnology in 2002. After a post-doctoral position at the University of Zürich at the Institute of Medical Virology, I returned to ETHZ, where I started to develop my research interest in engineering of cellular production systems.

My research group focuses on the rationale design of novel and improved production organisms using state-of-the art molecular biology tools in combination with high throughput screening approaches.

Every day, all over the world, baker’s yeast is used to make food and drink. Many societies have been using yeast for such purposes for thousands of years. Yeast’s importance has led to it being well-studied. In recent years, this has resulted in yeast being used not only in the production of food, but also in the manufacturing of biopharmaceuticals. Using yeast as working horse, we create new ways to make “tried and tested” products such as therapeutic antibodies – however in a more efficient way than with the existing production methods. The areas of our research are related to recombinant protein production in general and we develope key expertise in protein N-glycosylation and protein folding and secretion. In addition, my research group is developing novel approaches for biosynthesis of biologically active oligosaccharides and utilizing molecular biotechnology for development of materials.

Our research is published in the leading journals of the field and the most cited article received more than 100 citations. In addition, the research has resulted in several patent applications.

Full researcher profile
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  • Molecular biotechnology, Visiting Professor


Similarity Index for the Fat Fraction between Breast Milk and Infant Formulas

Sanna Hokkanen, Alexander D. Frey, Baoru Yang, Kaisa M. Linderborg 2022 Journal of Agricultural and Food Chemistry

Production of galactosylated complex-type N-glycans in glycoengineered Saccharomyces cerevisiae

Mari A. Piirainen, Heidi Salminen, Alexander D. Frey 2022 Applied Microbiology and Biotechnology

The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts

Mari A. Piirainen, Alexander D. Frey 2022 Frontiers in Molecular Biosciences

Partitioning of the milk fat globule membrane between buttermilk and butter serum is determined by the thermal behaviour of the fat globules

Sanna P. Hokkanen, Riitta Partanen, Annamari Jukkola, Alexander D. Frey, Orlando Rojas Gaona 2021 International Dairy Journal

Production of Glucose 6-Phosphate From a Cellulosic Feedstock in a One Pot Multi-Enzyme Synthesis

Anne Usvalampi, He Li, Alexander D. Frey 2021 Frontiers in Bioengineering and Biotechnology

Mining Data From Plasma Cell Differentiation Identified Novel Genes for Engineering of a Yeast Antibody Factory

Essi V. Koskela, Alina Gonzalez Salcedo, Mari A. Piirainen, Heidi A. Iivonen, Heidi Salminen, Alexander D. Frey 2020 Frontiers in Bioengineering and Biotechnology

Production and characterization of Aspergillus niger GH29 family α-fucosidase and production of a novel non-reducing 1-fucosyllactose

Anne Usvalampi, Marcela Ruvalcaba Medrano, Hannu Maaheimo, Heidi Salminen, Olli Tossavainen, Alexander D. Frey 2020 Glycoconjugate Journal

Tailoring N-Glycan Biosynthesis for Production of Therapeutic Proteins in Saccharomyces cerevisiae

Mari A. Piirainen, Heidi Salminen, Alexander D. Frey 2019 Methods in molecular biology (Clifton, N.J.)

Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach

Jorg C. de Ruijter, Essi V. Koskela, Jatin Nandania, Alexander D. Frey, Vidya Velagapudi 2018 Yeast