Ari Koskelainen
Institutionen för neurovetenskap och medicinsk teknik

Ari Koskelainen

Professor

Kontakt information

Postadress
Otakaari 3
Mobile phone
+358503673768
Full researcher profile
https://research.aalto.fi/...

Beskrivning

My main research interests are the molecular mechanisms of photoreceptor cell signaling in the retina of the vertebrate eye, and increasingly, the mechanisms of neurodegeneration in certain retinal diseases. My research aims at developing novel therapies for age-related macular degeneration (AMD), and it involves the use of genetically modified mice and the use and development of state-of-the-art electrophysiological recording techniques and approaches, from single-cell recording to electroretinography (ERG) across the isolated retina and in vivo ERG.

Publikationer

Institutionen för neurovetenskap och medicinsk teknik

In vivo monitoring of mouse retinal temperature by ERG photoresponses

Publishing year: 2019 EXPERIMENTAL EYE RESEARCH
Institutionen för neurovetenskap och medicinsk teknik

Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp

Publishing year: 2019 Scientific Reports
Institutionen för neurovetenskap och medicinsk teknik

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Publishing year: 2019 Redox Biology
Institutionen för neurovetenskap och medicinsk teknik

Electrophysiological determination of phosphodiesterase-6 inhibitor inhibition constants in intact mouse retina

Publishing year: 2018 Toxicology and Applied Pharmacology
Institutionen för neurovetenskap och medicinsk teknik

Transretinal ERG in studying mouse rod phototransduction

Publishing year: 2017 Investigative Ophthalmology and Visual Science
Institutionen för neurovetenskap och medicinsk teknik, Institutionen för filmkonst och scenografi

Spaces of the Abnormal, Poveglia II

Publishing year: 2017
Institutionen för neurovetenskap och medicinsk teknik

A Novel Method for Mouse Retinal Temperature Determination Based on ERG Photoresponses

Publishing year: 2017 Annals of Biomedical Engineering
Institutionen för neurovetenskap och medicinsk teknik

Lack of P4H-TM in mice results in age-related retinal and renal alterations

Publishing year: 2016 HUMAN MOLECULAR GENETICS
Institutionen för neurovetenskap och medicinsk teknik

Retinal temperature determination ex vivo based on ERG photoresponses

Publishing year: 2015 Investigative Ophthalmology and Visual Science
Institutionen för neurovetenskap och medicinsk teknik

Determination of basal PDE activity in WT, GCAPs(-/-) and GCAPs(-/-) rec(-/-) mice rods

Publishing year: 2015 Investigative Ophthalmology and Visual Science