Department of Bioproducts and Biosystems

Bioprocess Engineering

Bioprocess engineering group led by Prof. Sandip Bankar is dedicated to develop sustainable, efficient yet economic bioprocesses for industrially valuable biomolecules such as bacterial cellulose biobutanol, glucose oxidase, polylysine, polyglutamate, succinic acid, etc.
Bacterial cellulose
Bacterial cellulose research

We work in the areas of fermentation and purification of biomolecules, protein engineering for enhanced yields and metabolic engineering. Currently, we are also working to synthesise bio-based materials from sustainable biomass and use various statistical tools, general kinetic reactions and metabolic engineering approaches to simulate the data and carefully studies biosynthetic pathways to divert the energy flux towards desired product. The laboratory has been actively working on conversion of lignocellulosic biomass into biochemicals, with special emphasis on improved bioprocesses for biofuels, proteins and therapeutic molecules.

Research themes:

  1. Production and downstream processing of biomolecules

  2. Bioprocess development using statistical tools and modelling

  3. In-situ bacterial cellulose modification

Production and downstream processing of biomolecules:

Bioprocess engineering lab emphasizes on fermentative production, metabolic engineering and downstream processing of biochemicals. The second-generation biomasses (such as lignocellulosic) are being explored to produce range of biomolecules viz. liquid biofuels, acids, enzymes, and biopolymers as well as therapeutic proteins, high fiber products and rare sugars. We also study simultaneous saccharification and fermentation in a consolidated bioprocess.

Bioprocess development using statistical tools and modelling:

We are working to tackle the challenges associated with gaseous mass transfer in an advanced fermentation systems such as modified airlift bioreactor. Our efforts also include design of continuous multistage bioreactors coupled with in-situ product recovery. Laboratory research also encompasses modeling and control of continuous bioprocess using artificial neural network.

In-situ bacterial cellulose modification:

We are also striving to utilise in-situ bacterial cellulose modifications for its high end applications. We have utilized second generation biomass to produce in-situ bacterial cellulose composites with improved chemical and mechanical properties. Single step cellulose modification using controlled bioprocess is being studied in our group.

CHEM flag


Bioprocess engineering group is mainly involved in teachings of related subjects. It mainly includes bioreactor design, control, and its operation and study various cellular level phenomenon. Design of industrial bioprocesses including mass- and energy balances, and their techno-economic assessment is also one of the highlights in our bioprocess related courses.

Professor Sandip Bankar is currently heading ‘Biotechnology’ major master’s program at School of Chemical Engineering since 2017. Besides, he teaches Bachelor level courses.

Bachelor level courses:

  • CHEM-C2310-BioprocessTechnology I (5Cr)
  • CHEM-C1300-Fundamental Biosciences (5Cr)

Master level courses:

  • CHEM-E3140-Bioprocess technology II (5Cr)
  • CHEM-E3205-Bioprocess optimization and simulation (5Cr)


The Bioprocess engineering group:

Chem prof Sandip Bankar

Professor Sandip Bankar, head of the research group:

Prof. Sandip is working at Aalto University since March 2016 to develop bioprocesses of value-added bio-molecules/chemicals/materials. Fermentation and purification of biomolecules is the core of his research interest. His work on ‘bioprocess development of biobutanol for commercial interest’ is noteworthy. Sandip is also acting as an advisor/consultant to couple of start-ups in Finland to design their bioprocesses and assess the market feasibility.

Earlier Sandip earned Bachelor of Pharmacy degree in 2005 and switched his interest to Bioprocess technology during Master of Technology studies in 2007. He was then awarded a PhD degree in Bioprocess Technology from Institute of Chemical Technology (ICT), Mumbai India in 2012. Soon after that Sandip joined Aalto University as a post-doctoral research fellow to advance his bioprocess engineering skills. Sandip was then honoured with a prestigious DST-INSPIRE faculty award (IIT grade Assistant Professor) from Department of Science and Technology, Government of India in 2014.

Team members' biographies:

Bioprocess Engineering Group

Latest publications:

Reducing agents assisted fed-batch fermentation to enhance ABE yields

Vijaya Chandgude, Teemu Välisalmi, Juha Linnekoski, Tom Granström, Bruna Pratto, Tero Eerikäinen, German Jurgens, Sandip Bankar 2021 Energy Conversion & Management

Efficient strategy to alleviate the inhibitory effect of lignin-derived compounds for enhanced butanol production

Shrikant A. Survase, Pranhita Nimbalkar, German Jurgens, Tom Granström, Prakash Chavan, Sandip Balasaheb Bankar 2021 ACS Sustainable Chemistry and Engineering

Production of Glucose 6-Phosphate From a Cellulosic Feedstock in a One Pot Multi-Enzyme Synthesis


Adsorptive removal of unsaturated fatty acids using ion exchange resins

Prakash V. Chavan, Manisha A. Khedkar, Satchidanand R. Satpute, Sandip B. Bankar 2021 Journal of Chemical and Engineering Data

Inhibition of hyperthermostable xylanases by superbase ionic liquids

Hakim Hebal, Arno Parviainen, Sasikala Anbarasan, He Li, Laura Makkonen, Sandip Bankar, Alistair W.T. King, Ilkka Kilpeläinen, Said Benallaoua, Ossi Turunen 2020 Process Biochemistry

Solvent extraction of butanol from synthetic solution and fermentation broth : Batch and continuous studies

Manisha A. Khedkar, Pranhita R. Nimbalkar, Shashank G. Gaikwad, Prakash V. Chavan, Sandip B. Bankar 2020 Separation and Purification Technology

Biobutanol production from sugarcane straw : Defining optimal biomass loading for improved ABE fermentation

Bruna Pratto, Vijaya Chandgude, Ruy de Sousa, Antonio José Gonçalves Cruz, Sandip Bankar 2020 Industrial Crops and Products

An investigation on changes in composition and antioxidant potential of mature and immature summer truffle (Tuber aestivum)

Nirali Shah, Anne Usvalampi, Sandeep Chaudhary, Tuulikki Seppänen-Laakso, Sandesh Marathe, Sandip Bankar, Rekha Singhal, Salem Shamekh 2020 European Food Research and Technology

Novel multistage solid–liquid circulating fluidized bed

Manjusha A. Thombare, Dinesh V. Kalaga, Sandip B. Bankar, Rahul K. Kulkarni, Satchidanand R. Satpute, Prakash V. Chavan 2020 Particulate Science and Technology

Enhanced biobutanol production in folic acid-induced medium by using clostridium acetobutylicum NRRL B-527

Pranhita R. Nimbalkar, Manisha A. Khedkar, Prakash V. Chavan, Sandip B. Bankar 2019 ACS Omega
More information on our research in the Research database.
Research database
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